Ya-Ching Shen*†, Yu-Chi Lin†, Michael Y. Chiang‡, Sheau Farn Yeh§, Yuan-Bin Cheng†, and Chia-Ching Liao†
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China, Department of Chemistry, National Sun Yat-Sen University, Taiwan, Republic of China, and Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan, Republic of China
Abstract
Two novel triterpene dilactones, kadsuphilactones A (1) and B (2), were isolated from the Taiwanese medicinal plant Kadsura philippinensis. The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic methods, including two-dimensional NMR techniques, and confirmed by X-ray crystallographic analysis. Kadsuphilactone B (2) exhibited in vitro anti-HBV activity with IC50 values of 6 μg/mL by HBsAg enzyme immunoassay.
Yu-Chi Lin†, I-Wen Lo†, Shun-Ying Chen‡, Pi-Han Lin§, Ching-Te Chien‡, Sui-yuan Chang§, and Ya-Ching Shen*†
School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, Silviculture, Taiwan Forestry Research Institute, Taipei, Taiwan, and Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
Abstract
A novel triterpenoid, schinarisanlactone A (1), was isolated from the fruits of Schisandra arisanensis. Compound 1 possesses an unprecedented skeleton having a 5/7/7/5/7/5/6/5-fused octacyclic ring system. The structure of 1 was determined by 2D NMR techniques (COSY, HMQC, HMBC, and NOESY) and was confirmed by X-ray crystallographic analysis. Schinarisanlactone A (1) exhibited significant anti-HIV activity.
Yuan-Bin Cheng†, Tzu-Ching Liao†, I-Wen Lo†, Yu-Chen Chen†, Yuh-Chi Kuo‡, Shun-Ying Chen§, Ching-Te Chien§ and Ya-Ching Shen*†
School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, Department of Life Science, Fu-Jen University, Taipei Hsien, Taiwan, and Division of Silviculture, Taiwan Forestry Research Institute, Taipei, Taiwan
Abstract
A phytochemical investigation of the fruits of Schisandra arisanensis has yielded a novel triterpenoid, arisandilactone A (1). Compound 1 has an unprecedented skeleton having a 5/5/7/5/8/5-fused hexacyclic ring system. The structure of 1 was elucidated by spectroscopic methods, especially 2D NMR techniques (COSY, HMQC, HMBC, and NOESY) and was confirmed by X-ray crystallographic analysis. A plausible biosynthetic pathway for 1 is also discussed.
I-WenLoYu-ChiLinTzu-ChingLiaoShun-YingChenPi-HanLinChing-TeChienSui-yuanChangYa-Ching Shen
- Food Chemistry,
- Volume 136, Issue 2,
- 15 January 2013,
- Pages 1095-1099
Two novel highly oxygenated nortriterpenoids, schisarisanlactones A (1) and B (2), have been isolated from the fruits of Schisandra arisanensis, an endemic plant of Taiwan. Compounds 1 and 2 possess an unprecedented 5/5/7/5/5-fused pentacyclic ring system. The structures of both compounds were determined on the basis of spectroscopic analyses, especially 2D NMR and MS. A plausible biogenetic pathway of 1 was proposed. Schisarisanlactone A (1) showed significant anti-HIV activity.
