1. New and bioactive lignans from the fruits of Schisandra sphenanthera (華中五味子)
Hsin-ChanHuangaYu-ChiLinaAhmed EidFazaryaI-WenLoaChia-ChingLiawaYi-ZsauHuangbShorong-ShiiLioucYa-Ching Shen*,a
  1. Food Chemistry, 
  2. Volume 128, Issue 2, 
  3. 15 September 2011, 
  4. Pages 348-357

Abstract

Phytochemical investigation of the ethanol extract from the fruits of Schisandra sphenanthera has resulted in isolation of seven new oxygenated lignans (1–7), in addition to 11 known compounds (8–18). Their structures were determined on the basis of 2D-NMR (COSY, HMQC, HMBC and NOESY) analyses. The isolated components were evaluated with a reporter gene assay that measures their anti-liver fibrosis activity. Compounds 1, 2, 4, 11, 13, 14 and 18 exhibited significant anti-inflammatory activity on HSC-T6 test. 

2. Anti-liver fibrotic lignans from the fruits of Schisandra arisanensis and Schisandra sphenanthera (阿里山五味子 / 華中五味子)

  1. Bioorganic & Medicinal Chemistry Letters, 
  2. Volume 23, Issue 3, 
  3. 1 February 2013, 
  4. Pages 880-885
  1. Yu-Chen Chen, 
  2. Chia-Ching Liaw, 
  3. Yuan-Bin Cheng, 
  4. Yu-Chi Lin, 
  5. Ya-Ching Shen*

Abstract

Three new polyoxygenated C18-dibenzocyclooctadiene lignans, arisanschinins M and N (1and 2) and schisphenin A (3), together with eight related metabolites (4–11), were isolated from the fruits of Schisandra arisanensis and Schisandra sphenanthera, respectively. The structures of 1–3 were elucidated on the basis of extensive spectroscopic and 2D NMR (HSQC, HMBC, and NOESY) analyses. The configuration of the biphenyl moiety in the octadiene ring was determined by circular dichroism (CD). Compound 1 possessed an unprecedented 3-(1-hydroxypropan-2-yl)-3-methyl-1,4-dioxo-2-one lactonide ring system attaching at C-6/C-14. Pharmacological studies revealed that compounds 3, 4, 6, 7, and 10exhibited significant anti-hepatic fibrosis activity, while 9 and 11 showed cytotoxicity against HSC-T6 cells. The biogenetic pathway for compound 1 was also proposed.