1. Oxygenated Lignans from the Fruits of Schisandra arisanensis (阿里山五味子)
Yuan-Bin Cheng†, Meng-Ting Chang†, Yi-Wen Lo†, Ching-Jen Ho†, Yuh-Chi Kuo‡, Ching-Te Chien§, Shun-Ying Chen§, Shorong-Shii Liou⊥, Yao-Haur Kuo∥ and Ya-Ching Shen*†
School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Rd. Sec. 1, Taipei 100, Taiwan, Republic of China, Department of Life Science, Fu-Jen University, No. 510, Chung-Cheng Road, Hsinchuang, 242, Taipei Hsien, Taiwan, Republic of China, Division of Silviculture, Taiwan Forestry Research Institute, Taipei 100, Taiwan, Republic of China, Department of Pharmacy, Tajen University, Yen-Pou, Ping Tung Shien, Taiwan, Republic of China, and National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
J. Nat. Prod., 2009, 72 (9), pp 1663–1668
Abstract
Abstract Image

An acetone extract of the fruits of the Taiwanese medicinal plant Schisandra arisanensis has yielded 11 new oxygenated lignans. Four of these, named arisantetralones A−D (1−4), possess the aryltetralone skeleton, while the other seven, named arisanschinins F−L (5−11), are polyoxygenated C18-dibenzocyclooctadiene lignans. Structures were determined on the basis of spectroscopic analyses, especially 2D-NMR techniques. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Immunomodulatory activity of the isolated lignans was tested and evaluated. (增強體力)

2. Cyclomarins A−C, New Antiinflammatory Cyclic Peptides Produced by a Marine Bacterium (Streptomyces sp.) (海洋微生物)
Contribution from the Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204, and Department of Chemistry, Cornell University, Ithaca, New York 14853-1301
J. Am. Chem. Soc., 1999, 121 (49), pp 11273–
Abstract
Figure

Three new cyclic heptapeptides, cyclomarins A−C (1−3), were isolated from extracts of a cultured marine bacterium collected in the vicinity of San Diego, CA. The major metabolite, cyclomarin A (1), contains three common and four unusual (or unique) amino acids. The structures of the new metabolites were determined using 1D and 2D NMR methods, and the stereochemistry was determined from an X-ray crystal structure of the diacetate derivative of 1. Cyclomarin A (1) displays significant antiinflammatory activity in both in vivo and in vitro assays. (增強體力)

3. Eight new diterpenoids from soft coral Cespitularia hypotentaculata (叢羽珊瑚)
  1. Tetrahedron, 
  2. Volume 63, Issue 45, 
  3. 5 November 2007, 
  4. Pages 10914-10920
  1. Ya-Ching Shen* , 
  2. Ying-Ru Wu, 
  3. Jyun-Jhou Lin, 
  4. Kuang-Liang Lo, 
  5. Ashraf Taha Khalil

Abstract

Chemical investigation of the soft coral Cespitularia hypotentaculata resulted in the isolation of eight new diterpenes, cespihypotins E–L (1–8). The new metabolites comprise of six verticillene-type diterpenes, one cespitularane derivative, and one derivative with 14-membered lactone ring. The structures were determined through detailed spectroscopic analyses, especially high resolution ESIMS and 2D NMR techniques. The relative stereochemistry was deduced from NOESY spectrum and application of Mosher's ester technique. Immunomodulatory and antiviral activities of 1–8 were tested and evaluated. The biogenetic pathways for 1–8 were also proposed. (增強體力)
Graphical abstract

4. Chemical transformation of inocalophyllins, preparation of novel pyranocoumarines inocalocyclides (胡桐)
Tetrahedron Letters, Volume 45, Issue 1, 1 January 2004, Pages 187-189
Ya-Ching Shen* , Li-Tang Wang, Ching-Yu Chen
Abstract

Lactonization of inocalophyllins A (5) and B (6) with toluenesulfonic acid has yielded four novel pyranocoumarins, designated inocalocyclides A–D (1–4). This reaction involved a rare elimination of an isoprene unit and an ene cyclization.
Lactonization of inocalophyllins A and B with toluenesulfonic acid has yielded four novel pyranocoumarins 1–4. This reaction involved a rare elimination of an isoprene unit and an ene cyclization. (增強體力)